Author

P. Nagarkatti

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Open access Sep 2026

Delta-8-tetrahydrocannabinol ameliorates murine autoimmune hepatitis and is associated with epigenetic modulation of immune responses.

AIM OF THE STUDY Cannabinoids have gained attention for their ability to modulate immune responses and suppress inflammation. However, the effect of Δ8-THC, a minor cannabinoid found in Cannabis, has not been explored in autoimmune hepatitis. To address knowledge gap, the present study aimed to investigate the hepatopr...

H. Hamida, Khadija Kakar, Manikandan Palrasu et al. · International Immunopharmaco... · 0 citations

Open access Jul 2026

Δ8-THC—mediated PPARα activation mitigates murine autoimmune hepatitis by suppressing NLRP3 inflammasome Activity and oxidative stress 2259475

Test the hypothesis that Δ8-THC protects against autoimmune hepatitis (AIH) by activating PPARα to suppress inflammasome signaling and oxidative stress and demonstrates that Δ8-THC activates PPARα signaling to inhibit NLRP3 inflammasome activation and ROS production, thereby attenuating liver inflammation and highlight...

H. Hamida, Rohan Gupta, Manikandan Palrasu et al. · Journal of Immunology · 0 citations

Open access Jul 2026

Δ8-Tetrahydrocannabinol (Δ8-THC) attenuates LPS-induced acute respiratory distress syndrome (ARDS) through immune-endothelial reprogramming 2300199

Acute Respiratory Distress Syndrome (ARDS) is a severe inflammatory lung disorder associated with high mortality. Currently, there are no FDA-approved pharmaceuticals approved for treatment of this disorder. This study evaluated the therapeutic potential of Δ8-Tetrahydrocannabinol (Δ8-THC), a cannabinoid that is...

Shruthi Thada, Ahmed K. Aladhami, Chloe Nichols et al. · Journal of Immunology · 0 citations