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Author

P. Nissen

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Open access Jul 2026

Mechanistic Insights into Autoinhibition of the Human Flippase ATP8B1

It is demonstrated that a minimal peptide spanning residues 1216-1228, which bridges the A- and N-domains in the autoinhibited conformation, is sufficient to inhibit ATPase activity.

Michelle Juknaviciute Laursen, Mathilde Roth, P. Nissen et al. · 1 citation
Review Open access Aug 2026

Dimerization in the SLC12 family: Structural and biochemical perspectives.

It is becoming increasingly clear that large conformational changes in dimeric arrangements deserve attention, alongside other understudied areas like lipid interactions, nucleotide or N-terminal binding to the dimerization domains, and potential roles of the less described member SLC12A9.

Alexandra Náplavová, P. Nissen, R. K. Flygaard · 0 citations

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