Author

P. Northcott

2 papers indexed here

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Open access Aug 2026

Cell autonomous regional differences in oligodendrocyte lineage development and responses to oncohistone H3.3 K27M

It is suggested that histone H3.3 K27M mutations drive diffuse midline glioma by ablating intrinsic regional differences in oligodendrocyte development, selectively expanding immature oligodendrocyte precursor cell populations in the brainstem while disrupting normal differentiation programs.

Jared M. Andrews, K. Budd, C. Kwon et al. · Nature Communications · 0 citations

Open access Jul 2026

Circulating tumor DNA precision oncology enables effective and sensitive molecular diagnostics and actionable target detection in pediatric solid tumors - the INFORM experience

By optimizing preanalytical and bioinformatic tools for pediatric settings, this study improved plasma-based cancer detection, molecular tumor characterization, and identification of targetable alterations, laying the groundwork for integration into personalized medicine programs and clinical trials.

K. Maass, P. Puranachot, S. Volz et al. · Genome Medicine · 0 citations