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Author

P. Pioli

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2 papers indexed here

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Open access Jul 2026

Treatment Responses Alter Myeloid Activation in BRAF-Mutant Melanoma 2252856

This work establishes for the first time that BRAFi promotes myeloid-mediated induction of T cell activation, which is lost at resistance but can be rescued with the addition of CDDO- me, and provides the foundation for its potential use in combination therapies for melanoma.

Chen-Yu Wang, G. Torres, Helen C. Jarnagin et al. · 0 citations
Jul 2026

PI3K Delta Inhibition Alters CD8 T Cell Différentiation and Reprograms the Tumor Microenvironment Following Adoptive Immunotherapy 2247548

PI3Kδ inhibition programs T cells with stemness and metabolic fitness that favor Tpex differentiation, resist terminal exhaustion, and remodel the TME toward an inflammatory state, supporting a practical strategy to improve ACT efficacy in solid tumors.

Alexandrea Turnquist, Azka Javaid, F. Kolling et al. · 0 citations