Author

Poulikos I. Poulikakos

2 papers indexed here

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Oct 2026

MEKing Room: On the Quest for New Sources of Therapeutic Index in RAS/MAPK-Driven Cancers.

The RAS/MAPK pathway is among the most frequently dysregulated in human cancer, predominantly driven by activating mutations across RAS and BRAF in a broad spectrum of tumor types. The recent clinical validation of direct inhibitors of RAS, long considered undruggable, has reenergized the field and renewed focus on tar...

Bijaya Gaire, P. Poulikakos · Cancer Research · 0 citations

Review Open access Aug 2026

The past, present, and future treatment of BRAFV600‐mutant metastatic colorectal cancer: A comprehensive review

BRAFV600‐mutant metastatic colorectal cancer comprises a biologically distinct and clinically aggressive subset of metastatic colorectal cancer. Early attempts to apply single‐agent BRAFV600 inhibition failed because of rapid acquired resistance and reactivation of mitogen‐activated protein kinase signaling. Over the l...

I. Dirven, C. Ang, C. Bertels et al. · Cancer · 0 citations