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Review Open access Sep 2026

Bipolar androgen therapy in castration-resistant prostate cancer: Biological rationale, clinical evidence, and future directions

Androgen deprivation therapy remains the cornerstone of systemic treatment for advanced prostate cancer. However, progression to castration-resistant prostate cancer (CRPC) is almost inevitable. Supraphysiological androgen exposure can suppress tumor growth in selected biological contexts, a phenomenon termed the “test...

P. Rival, Jeffrey Jiang, L. Qu et al. · 0 citations

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