It is demonstrated that heterologous DNA/rAd5 vaccination generates antigen-specific CD8⁺ T cell memory with distinct clonal trajectories and cellular programs, providing new insights into how vaccine platform and antigen-specificity shape the durability and functional properties of HIV-1 specific cellular immunity.
Lenalidomide (Revlimid™), bortezomib (Velcade™), and dexamethasone, are used alone or in combination (RVd therapy) as first-line therapies for hematologic malignancies including the plasma cell dyscrasia, Multiple Myeloma (MM). The effects of RVd treatment on tumor cells have been documented, but little is known about...
Lucas T. Graybuck, L. Okada, Wei-Ling Chang et al.· bioRxiv· 0 citations
Fixed whole blood fixation protocol for high-dimensional spectral cytometry is implemented to preserve surface protein epitopes and enable high-dimensional flow cytometry without the need for immediate sample processing, revealing consistent identification of major immune lineages.
V. Parthasarathy, A. Heubeck, Tyanna J. Stuckey et al.· Cytometry Part A· 0 citations
A large-scale scATAC-seq resource that substantially improves immune cell annotation and regulatory inference and provides an unprecedented reference for immune cell gene regulatory circuits and a valuable resource for exploring the epigenome of human immune cells is presented.
Sydney Kuhl, Upaasana Krishnan, Andreas Tjaernberg et al.· Journal of Immunology· 0 citations
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