The need for improved implementation strategies to optimize guideline-directed therapy and dosing levels in the ageing HFrEF population is highlighted, with use of GDMT associated with better clinical outcomes, also among older patients.
J. J. N. Krabbe, M. I. Wilde, W. L. Verloop et al.· European Heart Journal· 0 citations
Mitochondrial heteroplasmy represents a fundamental determinant of mitochondrial function and disease, yet its consequences vary across different tissues. Although mitotic tissues possess mechanisms, such as cell division and mitochondrial turnover, to dilute or remove deleterious variants, postmitotic tissues lack thi...
Andriana Papadaki, Itamar Braga Dias, C. Maack et al.· Circulation Research· 0 citations
The findings underscore the need for implementation and dosing strategies that account for differences between men and women regarding GDMT implementation, side effects, change in left ventricular ejection fraction (LVEF), and clinical outcomes.
M. I. Wilde, J. J. N. Krabbe, L. J. Bouhuijzen et al.· European Heart Journal - Qua...· 0 citations
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