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P. Vemuri

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Review Oct 2026

Neuroimaging in the era of biologically defined Alzheimer's disease and disease-modifying therapy.

Neuroimaging is now a cornerstone of Alzheimer's disease care and a crucial discriminator tool for characterising brain injury across the lifespan and with emerging fluid biomarkers, neuroimaging supports accurate diagnosis, prognosis, and treatment monitoring.

Tammie L. S. Benzinger, P. Cogswell, A. Arani et al. · 2 citations
Open access Sep 2026

Are the factors associated with cognitive performance generalizable across cohorts?

Tau pathology in the presence of Aβ was a stronger predictor of cognition in ADNI than in U.S. POINTER, and this discrepancy was not explained by increased vascular risk or brain atrophy in U.S. POINTER.

Pei-Wei Liu, Theresa M. Harrison, H. Snyder et al. · 0 citations
Open access Aug 2026

EOAD-Signature Atrophy Predicts Dementia in Early-Onset MCI due to Alzheimer Disease

Findings support the potential value of EOAD-signature atrophy as an MRI-based biomarker for individualized prognostication and clinical trial stratification and support the potential value of EOAD-signature atrophy as an MRI-based biomarker for individualized prognostication and clinical trial stratification.

T. Paranhos, Yuta Katsumi, M. Brickhouse et al. · 0 citations
Open access Aug 2026

Concordance Between [18F]Flortaucipir PET Visual Reads and CenTauR-Based Quantification.

Generalized additive models examined clinical progression on the basis of visual and CenTauRz-based assessments of tau PET positivity and highlighted the need for new quantification approaches to better capture the complex patterns of tau deposition, important for early AD detection and monitoring.

Stamatia Karagianni, Alexis Moscoso, Sheelakumari Raghavan et al. · 0 citations
Open access Jul 2026

Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression.

Findings lend support for PVS-BG as an early indicator of small vessel dysfunction and WMH pathogenesis and suggest that PVS-BG may identify individuals at increased risk of progressive SVD.

Audrey Low, J. Gunter, Ming-Zhao Hu et al. · 0 citations
Open access Jul 2026

Diffusion MRI identifies a prolonged Pre-WMH Phase in Cerebral Small Vessel Disease

Diffusion MRI biomarkers were abnormal at least a decade before WMH abnormality in the population, revealing a prolonged phase of early SVD and highlighting their potential for SVD prevention.

P. Vemuri, Ming-Zhao Hu, Emily S. Lundt et al. · 0 citations

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