P. Zoppoli

Regulatory mutants of the Tbx1 gene alter transcription programs of lineage determination and patterning in early mesoderm

The Tbx1 gene is haploinsufficient in mice and in humans, where it causes a DiGeorge syndrome phenotype characterized by developmental deficits of the pharyngeal apparatus. TBX1 plays a critical role in the differentiation and regionalization of the cardiopharyngeal mesoderm lineage and its derivatives. Nevertheless, i...