Sep 2026
Disruption of cellular iron homeostasis by SRPX2-IRP1 interaction aggravates renal fibrosis in chronic kidney disease.
Findings reveal SRPX2 as a key pathogenic factor driving renal fibrosis by disrupting tubular iron homeostasis and Targeting the SRPX2-IRP1 regulatory axis presents a promising therapeutic strategy for slowing CKD progression.
Pei-Ran Yin, Lu-Miao Chen, M. Ding et al.
· Cell Death and Differentiati... · 0 citations