Review
Open access
Aug 2026
From gut microbiota-driven mucosal barrier disruption to myeloid-dominant immunosuppressive niches in colorectal cancer
Colorectal cancer (CRC) develops within a mucosal ecosystem in which epithelial barrier function, colonizing microbes, inflammatory signaling, and immune cell composition are closely interdependent. Immune checkpoint inhibitors have significantly altered treatment outcomes in patients with mismatch repair-deficient or...
Na Lu, Lei Zhang, Han-Yu Sun et al.
· Frontiers in Immunology · 0 citations