Mucoadhesive drug delivery systems are made to keep a formulation in close contact with the mucosal surface, this allows the drug to remain at the site of absorption for an extended period of time. The goal of this study is to create and assess mucoadhesive microspheres for the nasal delivery of Betahistine, as an anti...
Shakti Kasaudhan, Jai, Deo Pandey et al.· International Journal of Dru...· 0 citations
The objective of the present study was to develop and evaluate mucoadhesive microspheres of Tramadol hydrochloride for nasal delivery to enhance its bioavailability and provide rapid onset of action for pain management. Tramadol, a centrally acting analgesic, undergoes extensive first-pass metabolism when administered...
Harsh Vardhan Singh, Jai, Deo Pandey et al.· International Journal of Dru...· 0 citations
Formulate and evaluate mucoadhesive polymeric microspheres of Nitroglycerine for intranasal delivery to bypass hepatic first-pass metabolism, extend mucosal residence time, and provide controlled antianginal therapy. Microspheres were prepared by emulsification cross-linking using Chitosan with glutaraldehyde. Formulat...
Ashwani Kumar, Jai, Deo Pandey et al.· International Journal of Dru...· 0 citations
The primary objective of this investigation was to design, optimize, and critically evaluate patient-centric Mouth-Dissolving Tablets (MDTs) of Tramadol Hydrochloride (HCl) to circumvent dysphagia challenges, eliminate standard gastric lag times, and provide an ultra-rapid analgesic onset for managing acute breakthroug...
Verma Nikhil, Sant Bhagwan Prof, Jai Deo et al.· International Journal of Dru...· 0 citations
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