Cancer of the prostate is an important issue on a global scale, and therefore the identification of targets to support the development of therapy for this cancer should be a priority, particularly given the rise in cases of advanced prostate cancer and of patients who have developed resistance to the current standard o...
Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by insulin resistance, progressive β-cell dysfunction, and chronic hyperglycemia, leading to microvascular and macrovascular complications. Among current therapeutic strategies, inhibition of intestinal carbohydrate-hydrolyzing enzymes...
Shivank Sharma, Shubham Kumar, Pankaj Wadhwa· Mini-Reviews in Medical Chem...· 0 citations
VS-04 was identified as a promising oxadiazole–pyrazole lead with potent antiproliferative activity against prostate cancer cells, which was associated with AR modulation, oxidative stress, cell-cycle perturbation, and apoptotic cell death.
A target‐oriented overview of quinoline‐based anticancer agents reported between 2019 and 2025, covering quinoline, quinazoline, quinoxaline, and a few selected nonquinoline nitrogen‐containing heterocyclic derivatives is provided.
Amir Raza, Pankaj Wadhwa, Shivani Sharma· ChemMedChem· 0 citations
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