Pardeep Kumar

Computational small molecule drug discovery for multidrug-resistant tuberculosis: emerging targets and recent medicinal chemistry advances.

Tuberculosis (TB) remains a major global health challenge, further intensified by the emergence of multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains, which compromise the effectiveness of existing therapeutic regimens. Despite significant progress in TB chemotherapy, prolonged treatment durat...

Exploration of novel indolo[2,3-b]quinoxaline hybrids as InhA inhibitors: A multi-disciplinary approach involving synthesis, antimycobacterial evaluation and computational studies.

Design, Synthesis, Antimycobacterial Evaluation, and In Silico Investigation of Benzisothiazole‐Based Hydrazide Derivatives as Potential Anti‐Tuberculosis Agents

A series of novel benzisothiazole‐based hydrazide derivatives was rationally designed, synthesized, and evaluated for their antitubercular activity. Among the synthesized compounds, derivative 8k emerged as the most potent candidate, exhibiting a minimum inhibitory concentration (MIC) of 0.25 μg/mL, along with a high s...