Identification of repositioned inhibitors of pan-cancer proteasomal target as potential anti-proliferative candidates using a computational therapeutics approach.
UBE2C (Ubiquitin-Conjugating Enzyme E2C) is an E2 ubiquitin-conjugating enzyme involved in the ubiquitin-proteasome system which plays a crucial role in protein degradation and regulation of cell cycle. Overexpression of UBE2C can lead to mitotic defects, genomic instability and uncontrolled cell division, contributing...