Author

Pascal Bernard

2 papers indexed here

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Open access Oct 2026

Understanding the role of chromatin accessibility and compaction on loop extrusion dynamics

Loop extrusion by SMC complexes is a fundamental mechanism regulating the three-dimensional genome organization, but how these molecular motors navigate through the crowded, nucleosome-covered chromatin fiber remains an open question. Here, we develop a stochastic biophysical model of loop extrusion that explicitly cou...

Nicolas Pellet, C. L. Pastrana, Axel Delamarre et al. · bioRxiv · 0 citations

Open access Sep 2026

The rapid delivery of RNase H variants reveals distinct classes of RNA:DNA hybrids

Multiple lines of evidence suggest that RNase H1-sensitive RNA:DNA hybrids (thereafter referred to as ‘hybrids’) could disrupt the stability and restart of stalled replication forks. The prolonged over-expression of RNase H1 is the most popular method to manipulate hybrids in situ but it cannot discriminate between dir...

Amandine Basille, Yara Bawadi, Yea-Lih Lin et al. · bioRxiv · 0 citations