Author

Pathum Kossinna

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Open access Sep 2026

Prefibrotic bone marrow microenvironment is a hallmark of clonal hematopoiesis.

Clonal hematopoiesis of indeterminate potential is associated with systemic inflammation and increased malignant risk in humans, yet understanding of how it reshapes the bone marrow (BM) microenvironment has been limited. Using single-cell transcriptomic profiling of freshly isolated BM samples, combined with histologi...

Alicia G. Aguilar-Navarro, Gibran Edun, M. Gower et al. · Nature Immunology · 1 citation

Open access Aug 2026

IBAS: Interaction-bridged association studies discovering novel genes underlying complex traits

Interaction-Bridged Association Study is introduced, a general framework that incorporates pathway-level interaction patterns into genotype–phenotype association analysis without explicitly enumerating interactions, and provides a statistically robust and computationally tractable framework for incorporating interactio...

Dinghao Wang, Pathum Kossinna, Karen Ardila et al. · PLoS Computational Biology · 0 citations