Patrice Lassus

Tumor-derived Ilp8 and Upd3 contribute to intestinal progenitor cells depletion during cachexia in Drosophila larvae.

In animals, tumor development triggers systemic effects, impacting the physiology of distant organs. In Drosophila larvae, wing disc neoplastic tumors result in developmental delay and organ wasting reminiscent of cachexia. This paraneoplastic syndrome affects many organs, but its effects on the intestine, a key organ...