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Patricia Ferreira

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Open access Aug 2026

Functional plasticity of AIF revealed by dimerization and CHCHD4 interaction states

Apoptosis-inducing factor is a mitochondrial flavoprotein that links redox metabolism to mitochondrial homeostasis through its interaction with the disulfide relay protein CHCHD4. Although NADH-dependent AIF dimerization has been proposed as the activated state mediating CHCHD4 engagement, whether it is strictly requir...

Olga Soriano, Soraya Hernández-Hatibi, Rebeca Gracia-Domingo et al. · 0 citations

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