Bridge recombinases from the IS110 family of transposons, such as IS621, associate with a bridge RNA (bRNA) to mediate programmable recombination between donor DNA and target DNA1,2. Although insertion is mediated by the recombinase–bRNA complex, it remains unknown how IS621 elements are excised from host genomes to fo...
Masahiro Hiraizumi, Januka S. Athukoralage, Nicholas T. Perry et al.· Nature· 4 citations· ⚡1
The performance and flexibility of State set the stage for scaling the development of AI models of cell state, a machine learning model that predicts perturbation effects while accounting for cellular heterogeneity within and across experiments.
Abhinav K. Adduri, Dhruv Gautam, Beatrice Bevilacqua et al.· Cell· 2 citations
Single-cell RNA sequencing has transformed cell biology by enabling precise transcriptomic measurements of individual cells. The Sequence Read Archive (SRA) is the largest public repository of sequencing reads, yet much of it remains underutilized due to unstandardized metadata. Here, we introduce scBaseCount, a databa...
Nicholas D. Youngblut, Christopher Carpenter, Arshia Nayebnazar et al.· Cell· 1 citation
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