Patrick Ho

Deletion of a distal IRF4 element prevents inflammation-induced reprogramming of human regulatory T cell fate

Regulatory T (Treg) cells in mice can lose lineage identity and acquire proinflammatory functions, but whether human Treg cells are similarly susceptible to cytokine-driven destabilization remains unclear. Here we established an in vitro model of human Treg cell destabilization defined by silencing of the lineage-speci...