Patrick M. Sung

PCNA–RECQL5–RPRD1B recruit repair components to stressed replication forks to promote survival of BRCA1-deficient cancer cells

Abstract Given their defect in homologous recombination, BRCA1-deficient cancers use polymerase theta (POLQ) microhomology-mediated end joining (MMEJ) for repair of stressed replication forks. We found that BRCA1-deficient cells repress microRNA (miR) 4485-3p, and reconstituting expression of this miR resulted in the d...

Mechanisms and disease relevance of DNA break repair pathway choice.

The1H, 15N and13C backbone resonance assignments of an intrinsically disordered region (124–270) of BRCA1 associated RING domain 1 (BARD1)

The backbone resonance assignments of a BARD1 IDR construct spanning residues 124–270 are reported, providing a foundation for future studies aimed at understanding how the disordered regions of BARD1 interact with various binding partners, and cooperates with itself and BRCA1 to regulate genome stability.

The 1H, 15N and 13C backbone resonance assignments of an intrinsically disordered region (467–696) of breast cancer type 1 susceptibility protein (BRCA1)

The backbone resonance assignments of a BRCA1 IDR construct spanning residues 467–696 are reported, providing a foundation for future studies aimed at understanding how the disordered central region of BRCA1 contributes to homologous recombination, interactions with BARD1, and overall BRCA1 tumor suppressor function.