Patrycja M. Forster

Neuronal regulation of intestinal stem cells dictates immune homeostasis.

The intestinal epithelium undergoes continuous regeneration driven by intestinal stem cells (ISCs) residing within the crypt niche. Traditionally, this niche has been viewed as a stromal signaling compartment governed by gradients of Wnt, bone morphogenetic protein, and Notch activity. However, recent advances have rev...