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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Paul E. Brennan

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Open access Oct 2026

DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells.

Histone lysine demethylase 4 (KDM4) enzymes are frequently overexpressed in cancer and are considered to be promising therapeutic targets. QC6352, which is widely used as a best-in-class KDM4 chemical probe, shows potent antitumor activity across cancer models. Using comprehensive chemical biology approaches in gliobla...

Jayden Sterling, Jacinda R. Holtsmark, George L. Joun et al. · 1 citation
Jul 2026

Cross-Ancestry Proteogenomic Analyses Identified New Therapeutic Insights for Ischemic Heart Disease.

A role for lipid-driven chronic inflammation in IHD etiology is supported, and treatment strategies simultaneously targeting multiple lipid and inflammation pathways should be prioritized for further research to improve drug treatment of IHD beyond statin therapy.

Mohsen Mazidi, N. Wright, A. Pozarickij et al. · 1 citation

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