Paul J. Pfaffinger

A combined computational and experimental study of the interaction between the voltage-gated potassium channel Kv4.3 and its auxiliary protein KChIP

Voltage-gated potassium (Kv) channels of the Kv4 subfamily are central regulators of neuronal and cardiac excitability. In particular, Kv4.3 plays a vital role in shaping the timing, frequency, and backpropagation of electrical signals in the brain and heart by generating fast transient currents at subthreshold membran...