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Author

Paul J. Thomson

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2 papers indexed here

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Open access Oct 2026

Immune checkpoint inhibition enhances memory T-cell responses to CEF(T), SARS-CoV-2 spike proteins and ChAdOx1 nCoV-19

ABSTRACT An extensive body of clinical and experimental evidence demonstrates that immune checkpoint blockade can invigorate recall immune responses. This phenomenon has previously been highlighted using ex vivo (healthy donor) and in vivo (immunotherapy patients) models of immune checkpoint inhibitor (ICI) administrat...

Sophie Grice, Joshua Gardner, Paul J. Thomson et al. · 0 citations
Open access Aug 2026

Shared and Distinct T‑Cell Receptor Characteristics of CD4+ and CD8+ Drug-Specific T‑Cells In Vitro Generated from Healthy Donors and Hypersensitive Patients

The initiation of T-cell-mediated drug hypersensitivity reaction requires the formation of a human leukocyte antigen (HLA)-peptide-drug-T-cell receptor (TCR) complex. While specific interactions between HLA molecules and drug antigens are well-defined, the characteristics of drug binding to the TCR are unclear. Herein,...

Kanoot Jaruthamsophon, Paul J. Thomson, J. Pratoomwun et al. · 0 citations

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