Author

Paul L. C. Feyen

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Review Open access Oct 2026

Amyloid-β plaque diversity across brain regions in Alzheimer’s disease and its relation to major clinicopathological traits

Amyloid beta (Aβ) deposition and tau accumulation are neuropathological hallmarks of Alzheimer’s disease (AD). While Aβ deposits present with a wide morphological variety, a comprehensive, cross-regional overview of Aβ plaque composition in AD and associations with clinicopathological traits are missing. In this study,...

Antonia Neubauer, Paul L. C. Feyen, S. Pekrun et al. · Acta Neuropathologica · 0 citations

Open access Sep 2026

Axonal Branch Points of Parvalbumin Interneurons are Focal Sites of Tau-Induced Degeneration

Tau aggregation, a defining feature of tauopathies, commonly appears as neuropil threads within neurites including axons. However, the affected neuronal populations and the spatial organization of axonal vulnerability remain poorly defined. Here, following identification of Tau accumulation in parvalbumin (PV) interneu...

Paul L. C. Feyen, Yu-Xiao Zhang, Theresa Niedermeier et al. · bioRxiv · 0 citations

Open access Aug 2026

Molecular Disease Stages of Oligodendrocytic and Neuronal Tau Burden in Progressive Supranuclear Palsy

Background Progressive supranuclear palsy (PSP) is a primary tauopathy defined by the accumulation of 4R tau isoforms in neurons, oligodendrocytes and astrocytes. Despite evidence of genetic susceptibility operating through glial cell types, it remains poorly understood how cell type-specific epigenetic-transcriptional...

N. Briel, Viktoria C. Ruf, Paul L. C. Feyen et al. · bioRxiv · 0 citations