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Paul R. Sargunas

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Open access Jul 2026

Uhrf1 loss disrupts Ctcf-associated chromatin organization during early mouse embryogenesis

These findings identify Uhrf1 as a central regulator that tightly couples DNA methylation maintenance to 3D genome organization during gastrulation, thereby, directing early lineage specification and positioning Uhrf1 as a pivotal mediator of epigenetic information transfer during early embryogenesis.

Agata Kurowski, Bohan Zhu, Yifei Sun et al. · 0 citations