Abstract Objectives This article summarizes the architecture, design principles, and implementation strategy of the ATRI Laboratory Information Management System (LIMS), a cloud‑native, open‑source platform supporting biomarker‑driven Alzheimer’s disease (AD) clinical research. The system addresses challenges associate...
G. Jimenez-Maggiora, S. Bruschi, S. Abdel-Latif et al.· JAMIA Open· 0 citations
Sex differentially shapes aging, neurodevelopment, and neurodegenerative diseases such as Alzheimer’s disease (AD). Yet, most biological aging clocks (AI-predicted age minus chronological age) were trained on sex-pooled samples and implicitly assume sex invariance. Here, we develop 38 sex-specific biological aging cloc...
These findings uncover protein signatures that reflect underlying AD biology and provide a foundation for stage-specific biomarkers and therapeutic targeting, with important implications for patient stratification and personalized intervention strategies.
Saima Rathore, E. Dammer, Anantharaman Shantaraman et al.· Molecular Neurodegeneration· 0 citations
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