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Paulina J. Dziubanska-Kusibab

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Review Open access Sep 2026

Targeting the Androgen Receptor and Associated Cofactors in Prostate Cancer: Novel Approaches and Future Perspectives

Following the first approval for prostate cancer (PCa) treatment of competitive antagonists of the androgen receptor (AR) function that bind to the androgen-binding pocket, much progress has been achieved regarding compound efficacy and specificity. Second-generation compounds and androgen synthesis blockers are now st...

Paulina J. Dziubanska-Kusibab, Thibaud Jourdan, B. Haendler · 0 citations
Jul 2026

Protein Language Model-Based Fitness Estimates Facilitate Resistance Mutation Identification

Results show that protein fitness estimates can facilitate the identification of resistance mutations by filtering mutations with a low estimated fitness, indicating that protein language model-based protein fitness estimates could be a computationally efficient method to filter mutations without having to model the ne...

Dominik Schwarz, Sven H. Giese, Akansha Gupta et al. · 0 citations

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