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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Paulo C. T. Souza

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Open access Sep 2026

Signal peptidase complexes set species-specific rules for signal peptide cleavage

Protein secretion is essential for cell function and begins when signal peptides direct nascent proteins into the secretory pathway, where they are cleaved by the signal peptidase complex (SPC). Although this pathway is highly conserved, signal peptides do not always function efficiently across species, and the molecul...

Yeonji Chung, Gilberto P. Pereira, Young June Lee et al. · 0 citations
Open access Aug 2026

Towards transferable explicit-solvent coarse-grained models for biomolecular condensates

Biomolecular condensates formed by intrinsically disordered proteins require molecular models that accurately describe proteins in both dilute solution and condensed phases. Explicit-solvent coarse-grained models offer an attractive balance between chemical resolution and computational efficiency. Yet, it remains uncle...

Fran Bačić Toplek, L. Borges-Araújo, Kresten Lindorff-Larsen et al. · 0 citations
Open access Aug 2026

The Sec11 C-terminal short helix promotes productive engagement of internal signal sequences with the signal peptidase complex

Investigating the function of Sec11 CTS, the catalytic subunit of the SPC, found that it stabilizes internal signal sequences for productive engagement with SPC, and suggests that the Sec11 CTS specifically stabilizes internal signal sequences for productive engagement with SPC.

Yeonji Chung, Mariia Borbuliak, Sanghun Hwang et al. · 0 citations

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