Author

Pavithra Mahadevan

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Open access Sep 2026

The filopodial scaffold polyphosphate dictates cell adhesion-versus-invasion decisions

Inorganic polyphosphate (polyP) is an ancient polymer conserved across all life, serving cell type- and location–specific functions in every major compartment. Yet its role at the plasma membrane, where it accumulates to peak levels in many primary cells, is largely unknown. Here we identify polyP as a stabilizing comp...

Akash Rai, Aanchal Jain, Hannah Zunker et al. · bioRxiv · 0 citations

Open access Sep 2026

Polyamines control inorganic polyphosphate levels during bacterial nitrogen starvation

Inorganic polyphosphate (polyP) is a ubiquitous, multifunctional biomolecule that supports stress survival in bacteria. During nitrogen (N) starvation, Escherichia coli rapidly accumulates polyP, which drives the formation of RNA–protein granules that sustain long-term survival. What triggers this upregulation has rema...

Jian Guan, Pavithra Mahadevan, Ursula Jakob · bioRxiv · 0 citations

Aug 2026

Intragenomic homologs with distinct phase behaviors broaden the range of cellular stress responses.

It is demonstrated here that the interaction between H-NS and StpA fine-tunes the physico-chemical properties of nucleoid-associated compartments, thereby preserving gene repression and optimizing bacterial growth under stress.

Jian Guan, Bikash R. Sahoo, Tyler S. Brant et al. · Molecules and Cells · 0 citations