Author

Pavla Fajtová

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Open access Sep 2026

Discovery of a new class based on 6-methoxypyrimidine as efficient low weight reversible inhibitors of SARS-CoV-2 main protease (Mpro) with antiviral activity.

A low molecular weight non-peptide, heterocyclic inhibitor, that inactivates Mpro, an important enzyme for the viral cycle and its inhibition affects replication and infection propagation in SARS-CoV-2.

I. S. Fortes, M. Lopes, T. H. M. Fernandes et al. · Bioorganic chemistry (Print) · 0 citations

Structure − Activity Relationship Study of Antimalarial Asparagine-Derived Proteasome Inhibitors

Cryo-EM structural studies reveal a novel binding pose of the inhibitor at the Pf 20S β 5 active site, explaining the enhanced activity of an N -cap sulfonamide modification compared to an N -cap amide, and offer insights into the development of next-generation antimalarial Pf 20S-targeting compounds with improved drug...

Hao Zhang, Da-Qiang Li, Hao-Chi Hsu et al. · 0 citations