Author

Pedro J. M. Sobral

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Open access Jul 2026

Synthesis and biological evaluation of oridonin derivatives as antiproliferative agents against colorectal cancer

Mechanistic studies and structure–activity relationship analysis identify compound 11b as a valuable scaffold for further development of novel anticancer agents targeting CRC, and reduce intracellular ROS levels and attenuated mTOR signaling.

Pedro J. M. Sobral, Rita Oliveira, Silvia Marín et al. · RSC Medicinal Chemistry · 0 citations