Author

Pedro M. F. Sousa

2 papers indexed here

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Open access Sep 2026

A Unified 3D Generative Model for Synthesizable Structure-Based Drug Design

LDDM (Large Drug Discovery Model) is introduced, a generative framework that supports a range of drug discovery tasks, including constrained and unconstrained docking, fragment linking and growing, and de novo design, and a programmable design algorithm that enables accurate design of synthetically accessible compounds...

Ilia Igashov, Arne Schneuing, Adrian W. Dobbelstein et al. · bioRxiv · 0 citations

Open access Jul 2026

A large-scale analysis of the R2TP chaperone network reveals its contribution to the assembly of INO80, SRCAP and TIP60

HSP90/R2TP is an essential quaternary chaperone composed of RPAP3, PIH1D1 and the RUVBL1/RUVBL2 AAA+ ATPases. These enzymes are also part of the INO80, SRCAP and TIP60 complexes, but the relationship between these chromatin remodelers and R2TP remains unclear. Here, we performed systematic analyses of the R2TP-specific...

Y. Abel, Manon Philippe, Laurence Decourty et al. · bioRxiv · 0 citations