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Author

Pei-Hong Li

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Open access Aug 2026

Multi-omics analysis identifies fibroblast IGFBP5 as a key target of anti-TNFα therapy in ulcerative colitis

Background Resistance to anti-TNFα therapy (e.g., infliximab) in ulcerative colitis (UC) remains a significant clinical challenge, with the underlying cellular and spatial mechanisms poorly understood. Methods We integrated bulk transcriptomics, single-cell RNA sequencing (scRNA-seq), and spatial transcriptomics (ST) f...

Pei-Hong Li, Yi-Kun Zhang, Liu-Qin Zhao et al. · 0 citations
Open access Sep 2026

Identification of Crohn’s disease-associated molecular signatures by integrative bioinformatics analysis and experimental validation

Crohn’s disease (CD) is a chronic inflammatory bowel disease with rising global incidence. Its multifactorial etiology involves genetic, environmental, microbial, and immunological factors. Current diagnostic methods are invasive and costly, underscoring the need for improved biomarkers and non-invasive tools for e...

Pei-Hong Li, Si-Qing Guo, Hong-Yi Hu et al. · 0 citations

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