The HIV-1 capsid, composed of capsid (CA) proteins arranged into a conical surface lattice, serves as a critical platform for host–pathogen interactions. Many host cofactors regulate HIV-1 infection by selectively recognizing the higher-order CA lattice rather than individual monomers or capsomers. Among these, Myxovir...
Ya-Nan Zhu, J. Rey, Juan Shen et al.· bioRxiv· 0 citations
Public T cell receptors (TCRs) recurrently emerge across individuals in response to common pathogens, yet the structural and biophysical basis distinguishing public from private clonotypes remains incompletely defined. Here, we combine epitope mapping, single-cell TCR sequencing, and single-particle cryo-electron m...
Caner Akıl, Yan-Chun Peng, Julia McCarthy et al.· Nature Communications· 0 citations
Chloroplast ribosomes synthesize plastid-encoded components of photosynthetic machinery, yet their structure and organization remain poorly understood. We combined cryo-focused ion beam milling, cryo-electron tomography and subtomogram averaging to determine native chloroplast ribosomes in Chlamydomonas reinhardtii. Th...
Zhen Hou, Yao Shen, Zhao-Bo Zhang et al.· bioRxiv· 0 citations
These findings define a comprehensive structural and dynamic framework for RNAPII NAC, yielding a “molecular movie” of RNAPII in action and revealing a fundamental principle by which the enzyme balances speed and fidelity through coordinated conformational dynamics.
Gangshun Yi, Qing-Rong Li, H. Holmberg et al.· Nature Communications· 1 citation
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