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Author

Pei-Nian Liu

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Sep 2026

Discovery of Dual PARP/GPX4 Inhibitors for the Treatment of Triple-Negative Breast Cancer

This work identified dual PARP/GPX4 inhibitors via a structure-based hybridization strategy and explored the dual-target antitumor effect in blocking the progression of TNBC, finding that compound 12 exhibited potent biochemical inhibitory activities against both PARP and GPX4.

Zi-An Wang, Rong-Ke Li, Jia-Dai Liu et al. · 0 citations

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