Author

Pei-Pei Liu

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Open access Sep 2026

Efficacy of letrozole combined with recombinant human growth hormone in boys aged ≥10 years with advanced bone age and impaired growth potential: a retrospective cohort study

Introduction In boys aged ≥10 years with advanced bone age and impaired growth potential (baseline height SDS < −1.5, BA-CA ≥1.5 years, and PAH < −2 SDS), growth hormone monotherapy, while promoting linear growth, fails to delay skeletal maturation, thus limiting therapeutic efficacy. Although letrozole combined with g...

Pei-Pei Liu, Xi-Yan Lu, Miao Huang et al. · Frontiers in Endocrinology · 0 citations

Open access Oct 2026

First-morning urinary luteinizing hormone and bone age decomposition for diagnosis of central precocious puberty in girls: a two-step prediction model study

The diagnosis of central precocious puberty (CPP) in girls relies on the invasive gonadotropin-releasing hormone (GnRH) stimulation test. Urinary luteinizing hormone (LH) is a noninvasive candidate biomarker, but evidence from Chinese populations and its integration into multivariable prediction frameworks remain l...

Miao Huang, Xi-Yan Lu, Pei-Pei Liu et al. · Frontiers in Endocrinology · 0 citations