Pei-Pei Xie

Design-Evolution Synergy Enables New-to-Nature Enzyme Chemistry

Directed evolution and machine-learning-assisted evolution have transformed biocatalysis by enabling rapid optimisation of catalytic performance within compatible protein scaffolds. In parallel, advances in deep-learning-driven de novo protein design have expanded accessible protein architectural space, enabling the ge...

Catalytic Redox-Neutral Decarboxylative Aromatization via Transfer Dehydrogenation

Arenes are fundamental structural motifs in organic molecules; therefore, methods for introducing aromatic rings are of broad importance. Traditional approaches that install arenes early followed by postfunctionalization sometimes struggle to achieve diverse substitution patterns, high chemoselectivity, or satisfacto...

Chiral oxazolidinones via biocatalytic aziridination of unactivated alkenes.