Pei-Qiang Ma

An Integrated DNA Origami-Based RNA Degrader for Targeted Degradation of Oncogenic Mutant KRAS mRNA

Targeting mutant KRAS represents a critical yet unmet therapeutic challenge across multiple malignancies, as the structural diversity of oncogenic variants and absence of druggable pockets have impeded the development of effective small-molecule inhibitors. Here, we report an integrated RNA degrader system constructe...