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Case report Open access Sep 2026

Case Report: Remarkable response to savolitinib plus chemotherapy and bevacizumab in second-line treatment of MET amplified colon cancer with liver metastasis

Background Metastatic colorectal cancer (mCRC) is associated with poor prognosis and low survival rates, with acquired resistance limiting the durability of standard therapies. Mesenchymal-epithelial transition factor (MET) amplification is a rare but potentially actionable molecular alteration that has been implicated...

Ying Huang, Pei Shu, Shi-Yuan Gu et al. · 0 citations
Jul 2026

Parallel 4-1BB Signaling in Dual DLL3/CD56-Targeting CAR-T Cells Triggers Adaptive Proliferation and Functional Persistence to Eradicate Small Cell Lung Cancer.

These findings establish a clinically translatable combinatorial framework to enhance the efficacy and durability of CAR-T therapy in solid tumors and establish a clinically translatable combinatorial framework to enhance the efficacy and durability of CAR-T therapy in solid tumors.

Yan-Na Lei, Di-Yuan Qin, Yan He et al. · 0 citations

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