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Author

Pei-Wen Wu

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Aug 2026

A Self‐Framed Nanoprodrug for Orchestrating Mitochondria‐Associated Membranes‐Mediated Cascade Amplification Loop to Potentiate Radiotherapy in Esophageal Squamous Cell Carcinoma

Radioresistance remains a pivotal factor in the failure of esophageal squamous cell carcinoma (ESCC) therapy. Here we report a hyaluronic acid‐modified, polyphosphazene‐based self‐scaffold nanoradiosensitizer (HDiSeH) that addresses the limitations of single‐organelle targeting. HDiSeH exhibited uniform nanoscale m...

Pei-Wen Wu, Wei-Bin Hu, Ming-Chao Mu et al. · 0 citations
Sep 2026

The tire antioxidant derivative 6PPD-quinone exacerbates IBD by targeting NR1H4-mediated lipid metabolism and mitochondrial dysfunction in human colon epithelial cells.

Findings reveal that 6PPD-Q increases IBD risk by interfering with lipid metabolism, disrupting mitochondrial function, upregulating inflammatory cytokines, and downregulating NR1H4, providing important evidence for understanding the risk posed by this emerging environmental pollutant to IBD and for developing preventi...

Pei-Wen Wu, Wei-Bin Hu, Gang Chen et al. · 0 citations

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