Pei-Xian Huang

Intestinal 3-methylindole exacerbates sepsis-induced neuroinflammation through microglial NLRP3 inflammasome activation

ABSTRACT Gut microbiota regulates neuroinflammatory responses involved in the pathogenesis of sepsis-associated encephalopathy (SAE). However, the underlying mechanism remains elusive. 16S rRNA sequencing of fecal samples revealed an expansion of the Enterobacteriaceae family in septic mice, and quantitative PCR furthe...