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Pei-Xiong Yuan

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Open access Jul 2026

Time-dependent effects of rapid-acting antidepressants in iPSC-derived neurons from treatment-resistant depression and healthy volunteers.

This study is the first to assess multiple putative rapid-acting antidepressants in parallel using an iPSC-derived neuron model and observed convergent and drug-specific changes in gene expression and pathway enrichment, supporting the use of human iPSC-derived neurons in antidepressant drug discovery.

J. Johnston, Gregory H. Jones, Shiyong Peng et al. · 0 citations

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