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Pei-Xue Li

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Open access Sep 2026

Multimodal neuroimaging and electrophysiological signatures in amnestic mild cognitive impairment with different amyloid-β deposition status: correlations with cognitive function and diagnostic value

Amnestic mild cognitive impairment (aMCI) is a heterogeneous transitional cognitive state between normal aging and dementia. Aβ positivity elevates dementia conversion risk but does not equate to prodromal Alzheimer’s disease (AD), and not all Aβ-positive aMCI individuals progress to clinical AD dementia. Distingui...

Yan Liang, Pei-Xue Li, Lin Liu et al. · Frontiers in Aging Neuroscie... · 0 citations

Open access Sep 2026

Gray matter atrophy mediates the association between cerebral hypometabolism and cognitive impairment in Alzheimer’s disease

Objective Alzheimer’s disease (AD) is characterized by amyloid deposition, brain hypometabolism, gray matter atrophy and cognitive decline, yet their causal interactions are poorly defined. This multimodal PET/MRI study explored regional gray matter volume (GMV) loss and glucose hypometabolism in AD patients, and clari...

Shi-Qi Zhao, Jian-Wen Chen, Pei-Xue Li et al. · Frontiers in Neurology · 0 citations