Jul 2026
A Topology-Programmed Circular DNAzyme Enables High-Precision Diagnosis of Metastatic Triple-Negative Breast Cancer.
A cyclization-provoked, size-reliant topological barrier that suppresses the catalytic core folding of DNAzymes, thereby governing their catalytic activity is uncovered, enabling more accurate, spatiotemporal regulation for future therapeutic interventions.
Kun Yuan, Yiwen Yan, Pei-Zhu Wang et al.
· Analytical Chemistry · 0 citations