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Review Open access Aug 2026

Myeloid-derived suppressor cells in laryngeal squamous cell carcinoma: an underexplored immunosuppressive axis and strategic target for overcoming checkpoint inhibitor resistance

Laryngeal squamous cell carcinoma (LSCC) shows a persistently low objective response rate to immune checkpoint inhibitors (ICIs) targeting the programmed death-1 (PD-1) pathway. Its immunosuppressive tumor microenvironment (TME), enriched in tumor-associated macrophages, immunosuppressive tumor-associated neutrophils (...

Guan-Jiang Huang, Xue-Sen Yang, Peijie Li et al. · 1 citation

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