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Author

Peng Bai

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Open access Sep 2026

A Calcipotriol-Responsive ZF10–ΔVDR Switch for Mammalian Transgene Regulation with Topical Induction In Vivo

These findings establish ZF10–ΔVDR as a calcipotriol-responsive switch with limited activation by endogenous vitamin D species, activity across multiple mammalian cell types, reversible regulation under the tested conditions, and compatibility with topical induction in vivo.

Hong Su, Shi-Ting Li, Guan-Yang Chen et al. · 0 citations
Open access Sep 2026

A Calcipotriol-Responsive ZF10–ΔVDR Switch for Mammalian Transgene Regulation with Topical Induction In Vivo

Background: Small-molecule-regulated gene switches are important tools for programmable mammalian cell engineering, and compact switches responsive to clinically familiar ligands that can be administered locally are particularly attractive for externally regulated transgene expression. Methods: Here, we developed ZF10–...

Hong Su, Shi-Ting Li, Guan-Yang Chen et al. · 0 citations

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